Formic Acid → HCID 14344237, compound

HRID 1650896Notes

Reaction equation

HRID 1650896 reaction equation
[C:1]([OH:5])(=[O:4])[CH:2]=O.[CH2:6]([C:8]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH3:16])[C:9]=1[NH2:10])[CH3:7].[CH:17](O)=[O:18]>>[CH2:6]([C:8]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH3:16])[C:9]=1[N:10]([CH:17]=[O:18])[CH2:2][C:1]([OH:5])=[O:4])[CH3:7]

Participants

4

Reactant 3

HCID 284Formic AcidHCID 760Glyoxylic AcidHCID 113692,6-Diethylaniline

Product 1

HCID 14344237HCID 14344237, compound

Conditions

Temperature
70 °C

Procedure

32.6 g (0.22 mole) of an approximately 50% strength aqueous glyoxylic acid solution were added dropwise to 14.9 g (0.10 mole) of 2,6-diethylaniline and 100 ml of formic acid at room temperature, with gentle warming. The mixture was stirred at 70° C. for 1 hour, with vigorous evolution of gas, the formic acid was distilled off up to an internal temperature of 120° C., the mixture was allowed to cool and was poured onto water and the solid was filtered off with suction and dired. 21.8 g of N-(2,6-diethylphenyl)-N-formylglycine of melting point 139-41° C. were obtained.

Workup

  1. distillationthe formic acid was distilled off up to an internal temperature of 120° C.
  2. temperatureto cool
  3. additionwas poured onto water
  4. filtrationthe solid was filtered off with suction

Sources & evidence

ORD record
ord-755d79a9d9f74f3b85acbbb7116e15c1
Source dataset
uspto-grants-1990_05
Patent number
US04925958

Reaction notes

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