HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridinium chloride → 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxyphenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 3-Chloro-2-p-methoxyphenoxy-5-trifluoromethylpyridine | HCID 19986019 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxyphenol | HCID 9795997 | — |
Reaction Steps
The product from (e) (2 g) was heated with pyridine hydrochloride (20 g) at 170°-180° C. for 6 hours. The mixture was cooled, diluted with dilute hydrochloric acid, and extracted with ether. The ether extracts gave an oily solid which was purified by preparative thin layer chromatography using silica as the adsorbent and 6% ethanol-chloroform as the solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04925947 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-853220d87bbf4fef93f3896e681b708b |
| Source note | uspto-grants-1990_05 |