Pyridinium chloride → 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxyphenol

HRID 1650910Notes

Reaction equation

HRID 1650910 reaction equation
[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl.N1C=CC=CC=1>Cl>[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 199860193-Chloro-2-p-methoxyphenoxy-5-trifluoromethylpyridine

Product 1

HCID 97959974-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxyphenol

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The product from (e) (2 g) was heated with pyridine hydrochloride (20 g) at 170°-180° C. for 6 hours. The mixture was cooled, diluted with dilute hydrochloric acid, and extracted with ether. The ether extracts gave an oily solid which was purified by preparative thin layer chromatography using silica as the adsorbent and 6% ethanol-chloroform as the solvent.

Workup

  1. temperatureThe mixture was cooled
  2. extractionextracted with ether
  3. customThe ether extracts gave an oily solid which
  4. customwas purified by preparative thin layer chromatography

Sources & evidence

ORD record
ord-853220d87bbf4fef93f3896e681b708b
Source dataset
uspto-grants-1990_05
Patent number
US04925947

Reaction notes

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