HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ampicillin → Cephradine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ampicillin | HCID 6249 | — |
| Reactant | Amoxicillin | HCID 33613 | — |
| Reactant | Phenylglycine, D- | HCID 70134 | — |
| Reactant | 7-Aminocephalosporanic acid | HCID 441328 | — |
| Product | Cephradine | HCID 38103 | — |
Reaction Steps
As an example, D-(-)-(4-hydroxyphenyl)-glycine and D-(-)-phenylglycine are key intermediates in the industrial synthesis of amoxycillin and ampicillin respectively; while D-(-)-2-amino-2-(1,4-cylcohexadien-1-yl)acetic acid may be conveniently be employed in the acylation of 7-amino-cephalosporanic acid to give cefradin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04925978 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-4789e74a0b4d4e25b7586dfdb24dd946 |
| Source note | uspto-grants-1990_05 |