HCID 15617368, compound → HCID 15617270, compound

HRID 1651005Notes

Reaction equation

HRID 1651005 reaction equation
[C:1]([O:4][CH2:5][C:6]1[C:7]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:8]([S:12]([NH:15]C(C)(C)C)(=[O:14])=[O:13])[CH:9]=[CH:10][CH:11]=1)(=[O:3])[CH3:2]>FC(F)(F)C(O)=O>[C:1]([O:4][CH2:5][C:6]1[C:7]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:8]([S:12]([NH2:15])(=[O:13])=[O:14])[CH:9]=[CH:10][CH:11]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 15617368HCID 15617368, compound

Product 1

HCID 15617270HCID 15617270, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 2.58 g of 3-acetoxymethyl-2-carboethoxy-N-(1,1-dimethylethyl)benzenesulfonamide in 25 mL of trifluoroacetic acid was stirred at room temperature overnight. Removal of the solvent on the rotovap followed by trituration with n-butyl chloride provided 2.0 g of a white solid, m.p. 98°-100° C.

Workup

  1. customRemoval of the solvent on the rotovap

Sources & evidence

ORD record
ord-b8cd77d55f424177996bd20d5c204091
Source dataset
uspto-grants-1990_05
Patent number
US04927453

Reaction notes

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