Hydrochloric Acid → HCID 86743942, compound

HRID 1651027Notes

Reaction equation

HRID 1651027 reaction equation
[ClH:1].[CH2:2]([OH:4])[CH3:3].O.[NH2:6][C@H:7]([C:19]([OH:21])=[O:20])[CH2:8][CH2:9][C:10]([NH:12][C@H:13]([C:16](O)=[O:17])[CH2:14][SH:15])=[O:11]>CCOCC>[ClH:1].[CH2:2]([O:4][C:16](=[O:17])[C@H:13]([CH2:14][SH:15])[NH:12][C:10](=[O:11])[CH2:9][CH2:8][C@@H:7]([C:19]([OH:21])=[O:20])[NH2:6])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 702Ethanol2×HCID 18639409HCID 18639409, compound

Product 1

HCID 86743942HCID 86743942, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

After 250 ml of hydrogen chloride-containing ethanol (7N HCl-EtOH) was added to a dehydrated ethanol suspension (750 ml) containing 50 g (about 185 mmol) of γ-L-glutamyl-L-cysteine monohydrate, the mixture was stirred at room temperature for 1 hour. Upon addition of hydrogen chloride, the suspension turned to a solution. The reaction solution was then poured into ether (7.5 l) which had been cooled to 0° C. beforehand and the mixture was kept stirring for 2 hours to make the crystals precipitate. Thus obtained product was separated by filtration to give 48.4 g (83%) of γ-L-glutamyl-L-cysteine ethyl ester hydrochloride salt.

Workup

  1. temperaturehad been cooled to 0° C. beforehand
  2. stirringthe mixture was kept stirring for 2 hours
  3. customThus obtained product was separated by filtration

Sources & evidence

ORD record
ord-90b09402964a45f88fe0dfaa77b34702
Source dataset
uspto-grants-1990_05
Patent number
US04927808

Reaction notes

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