Acetic Acid → Methyl Picolinimidate

HRID 1651038ノート

反応式

HRID 1651038 の反応式
ClC1C=CC=CC=1O[C:5]1[N:10]=[C:9]([C:11]#[N:12])[CH:8]=[CH:7][CH:6]=1.[Na].[C:18](O)(=[O:20])C>C[O-].[Na+].CO>[N:10]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[C:11](=[NH:12])[O:20][CH3:18]

参加物

6

反応物 3

HCID 176Acetic AcidHCID 5360545SodiumHCID 15100862HCID 15100862、化合物

生成物 1

HCID 152260Methyl Picolinimidate

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 10942334Sodium Methoxide溶媒

実験手順

6-o-Chlorophenoxy-2-cyanopyridine (10 g) was dissolved in a solution of sodium methoxide in methanol prepared from methanol (150 ml) and metallic sodium (0.50 g). After the solution was left to stand overnight, acetic acid (1.3 g) was added thereto, followed by concentration under reduced pressure. The resulting residue was dissolved in ether (200 ml) and insoluble materials were filtered out. The filtrate was concentrated under reduced pressure to obtain methyl 2-picoline imidate derivative.

後処理

  1. waitAfter the solution was left
  2. concentrationfollowed by concentration under reduced pressure
  3. dissolutionThe resulting residue was dissolved in ether (200 ml)
  4. filtrationinsoluble materials were filtered out
  5. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-d4ad2367ba5440c8bdc81ab8571889d4
出典データセット
uspto-grants-1990_05
特許番号
US04927827

反応ノート

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