Phenyl glycidyl ether → HCID 15034335, compound

HRID 1651121Notes

Reaction equation

HRID 1651121 reaction equation
[CH2:1]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:19]1[CH:21]([CH2:22][O:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:20]1>CC(O)C>[CH2:1]([N:8]([CH2:20][CH:21]([OH:19])[CH2:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:9][CH2:10][O:11][C:12]1[CH:13]=[CH:14][C:15]([OH:18])=[CH:16][CH:17]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 31217Phenyl glycidyl etherHCID 15034333HCID 15034333, compound

Product 1

HCID 15034335HCID 15034335, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of N-benzyl-2-(p-hydroxyphenoxy)ethylamine (2.5 g) and 1,2-epoxy-3-phenoxypropane (1.54 g) in propan-2-ol (50 ml) was heated under reflux for 72 hours. The solvent was removed by evaporation to give N-benzyl-N-(2-p-hydroxyphenoxyethyl)-2-hydroxy-3-phenoxypropylamine as an oil which was essentially pure as indicated by thin layer chromatography (TLC) [using silica plates and 5% methanol in dichloromethane as eluant] and was used without purification.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 72 hours
  3. customThe solvent was removed by evaporation

Sources & evidence

ORD record
ord-c00b3f85f147474a8e86d356e6f8aee4
Source dataset
uspto-grants-1990_05
Patent number
US04927836

Reaction notes

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