Sodium Hydroxide → HCID 14742801, compound

HRID 1651225Notes

Reaction equation

HRID 1651225 reaction equation
C[O:2][C:3](=[O:22])/[CH:4]=[CH:5]/[C:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:16][CH3:17])[CH:12]=2)[C:7]=1[CH2:18][CH2:19][CH2:20][CH3:21].[OH-].[Na+]>CO>[CH2:18]([C:7]1[C:8]2[C:13](=[CH:12][C:11]([O:16][CH3:17])=[CH:10][CH:9]=2)[CH2:14][CH2:15][C:6]=1/[CH:5]=[CH:4]/[C:3]([OH:22])=[O:2])[CH2:19][CH2:20][CH3:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14742789HCID 14742789, compound

Product 1

HCID 14742801HCID 14742801, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

As in Example 112, (E)-3-(1-butyl-3,4-dihydro-6-methoxy-2-naphthalenyl)-2-propenoic acid methyl ester (2.9 g) in methanol (12 mL) was treated with 2N sodium hydroxide solution (7 mL) at reflux for 1.5 hours. The usual work up provided 2.6 g of (E)-3-(1-butyl-3,4-dihydro-6-methoxy-2-naphthalenyl)-2-propenoic acid as an oil.

Workup

  1. temperatureat reflux for 1.5 hours

Sources & evidence

ORD record
ord-3abf69727e6748f68db2dec38f799888
Source dataset
uspto-grants-1990_05
Patent number
US04927838

Reaction notes

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