Sodium Hydroxide → HCID 14742794, compound

HRID 1651231Notes

Reaction equation

HRID 1651231 reaction equation
C[O:2][C:3](=[O:26])/[CH:4]=[CH:5]/[C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:16][CH3:17])[CH:12]=2)[C:7]=1[C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1.[OH-].[Na+]>CO>[CH3:17][O:16][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[C:7]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:26])=[O:2])[CH:15]=[CH:14]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14742782HCID 14742782, compound

Product 1

HCID 14742794HCID 14742794, compoundYield 92.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

As in Example 112, (E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid methyl ester (1.8 g) in methanol (10 mL) was heated at reflux with 1N sodium hydroxide solution (8 mL) for 1 hour. The usual work up provided 1.6 g of (E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid. Crystallization of a small portion from dichloromethane-ethyl acetate gave the analytical sample, mp 248°-249° C. Anal. Calcd for C21H18O4 : C, 75.43; H, 5.43 Found: C, 75.65; H, 5.70

Sources & evidence

ORD record
ord-752bc6b65b4a4ec88651a4ef81d65410
Source dataset
uspto-grants-1990_05
Patent number
US04927838

Reaction notes

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