Sodium Hydroxide → HCID 14742794, compound

Participants

Reaction Steps

As in Example 112, (E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid methyl ester (1.8 g) in methanol (10 mL) was heated at reflux with 1N sodium hydroxide solution (8 mL) for 1 hour. The usual work up provided 1.6 g of (E)-3-[6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid. Crystallization of a small portion from dichloromethane-ethyl acetate gave the analytical sample, mp 248°-249° C. Anal. Calcd for C21H18O4 : C, 75.43; H, 5.43 Found: C, 75.65; H, 5.70

Provenance & Evidence