Hydrochloric Acid → 2-Methoxyimino-3-oxobutyric acid

A 200 ml portion of the above 4N hydrogen chloride solution in 1,4-dioxane was added to 35.0 g of tert-butyl 2-methoxyimino-3-oxobutyrate and the thus-obtained solution was stirred at 23° to 25° C. for 13 hours. The supernatant was concentrated, 200 ml of methylene chloride was added to the residue for dissolution of the latter, 30 ml of 20% aqueous sodium chloride was added to the thus-obtained supernatant, the mixture was shaken, and the organic layer was separated, dried over 12 g of anhydrous magnesium sulfate and concentrated to dryness under reduced pressure to give 21.8 g of 2-methoxyimino-3-oxobutyric acid.

1. concentrationThe supernatant was concentrated
2. addition200 ml of methylene chloride was added to the residue for dissolution of the latter, 30 ml of 20% aqueous sodium chloride
3. additionwas added to the thus-obtained supernatant
4. stirringthe mixture was shaken
5. customthe organic layer was separated
6. dry with materialdried over 12 g of anhydrous magnesium sulfate
7. concentrationconcentrated to dryness under reduced pressure

ORD record

ord-5c92713264ff4dc699678e5af42a1f1f

Source dataset

uspto-grants-1990_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04927964