反应详情

To a solution of N-[3-(3-formylphenoxy)propyl]phthalimide (92.8 g, 0.3 mole), ethylene glycol (44 mL, 0.8 mole) in benzene (1.5 L) was added 3 g of p-toluenesulfonic acid and the mixture was refluxed under a Dean-Stark trap for 14 hours. The cooled mixture was extracted with 100 mL of saturated aqueous sodium bicarbonate and then with 200 mL of saturated aqueous sodium chloride. The organic phase was dried and evaporated under reduced pressure to give 119.4 g of the title compound which crystallized on standing.

1. temperaturethe mixture was refluxed under a Dean-Stark trap for 14 hours
2. extractionThe cooled mixture was extracted with 100 mL of saturated aqueous sodium bicarbonate
3. customThe organic phase was dried
4. customevaporated under reduced pressure