反应详情

The 1-amino-2-{3-[3-(1,3-dioxolan-2-yl)phenoxy]propylamino}-1-cyclobutene-3,4-dione (11.66 g, 0.037 mole) was suspended in a solution of 200 mL of 95% ethanol and 20 mL of aqueous 2.0N HCl. The suspension was stirred at ambient temperature for 2 hours, then filtered (slowly) and dried in vacuo to give 9.85 g of crude title compound. Recrystallization from 150 mL of 95% ethanol and 35 mL of aqueous 1N HCl yielded 5.74 g of purified title compound; mp=203°-206° C.

1. filtrationfiltered (slowly) and
2. customdried in vacuo