Tert-butyl 2-oxoacetate → HCID 13773282, compound

HRID 1651452Notes

Reaction equation

HRID 1651452 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:11][NH2:12])=[S:10])=[CH:5][CH:4]=1.[C:13]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])(=[O:16])[CH:14]=O>CO>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[S:10][CH:14]([C:13]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[NH:12][N:11]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 10986247Tert-butyl 2-oxoacetateHCID 13773281HCID 13773281, compound

Product 1

HCID 13773282HCID 13773282, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product of step d) (3.0 g) was stirred at room temperature under nitrogen with t-butyl glyoxylate (2.0 g) in methanol (100 ml) for 18 hours. The mixture was evaporated and the residue purified by flash chromatography (ether/petroleum ether 1:3) to afford the sub-title compound (3.9 g) as a pale yellow solid. mp 71°-72°.

Workup

  1. customThe mixture was evaporated
  2. customthe residue purified by flash chromatography (ether/petroleum ether 1:3)

Sources & evidence

ORD record
ord-88d368ca307744a9a9f384e2b268c365
Source dataset
uspto-grants-1990_05
Patent number
US04927822

Reaction notes

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