Diethyl Ether → HCID 13773300, compound

HRID 1651460Notes

Reaction equation

HRID 1651460 reaction equation
[C:1]([S:4][CH2:5][CH2:6][C:7](Cl)=[O:8])(=[O:3])[CH3:2].[F:10][C:11]([F:34])([F:33])[C:12]1[CH:17]=[CH:16][C:15]([C:18]2[S:22][CH:21]([C:23]([O:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[O:24])[NH:20][N:19]=2)=[CH:14][CH:13]=1.C(OCC)C>C1(C)C=CC=CC=1>[C:1]([S:4][CH2:5][CH2:6][C:7]([N:20]1[N:19]=[C:18]([C:15]2[CH:16]=[CH:17][C:12]([C:11]([F:34])([F:10])[F:33])=[CH:13][CH:14]=2)[S:22][CH:21]1[C:23]([O:25][CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)=[O:24])=[O:8])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 129431223-(Acetylsulfanyl)propanoyl chlorideHCID 13773299HCID 13773299, compound

Product 1

HCID 13773300HCID 13773300, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3-Acetylthiopropanoyl chloride (0.36 g), poly (4-vinyl pyridine) (0.8 g) and the product from step b) (0.8 g) were stirred together in dry toluene (30 ml) under an atmosphere of nitrogen for 20 hours. Diethyl ether was added and the solid was filtered off and washed with diethyl ether. The filtrate was evaporated under reduced pressure and the resulting product was crystallised from ethanol to yield the sub-title product (0.9 g) as a white solid. mp 120°-121°.

Workup

  1. filtrationthe solid was filtered off
  2. washwashed with diethyl ether
  3. customThe filtrate was evaporated under reduced pressure
  4. customthe resulting product was crystallised from ethanol

Sources & evidence

ORD record
ord-c30eb2eb8e85425d814aa10f5383e469
Source dataset
uspto-grants-1990_05
Patent number
US04927822

Reaction notes

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