Glyoxal → HCID 10902530, compound

HRID 1651500Notes

Reaction equation

HRID 1651500 reaction equation
[CH2:1]([PH2:5])[CH:2]([CH3:4])[CH3:3].[CH:6]([CH:8]=[O:9])=[O:7]>O1CCCC1>[CH2:1]([P:5]1[CH:6]([OH:7])[CH:8]([OH:9])[P:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[CH:6]([OH:7])[CH:8]1[OH:9])[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 7860GlyoxalHCID 6451630Phosphine, (2-methylpropyl)-

Product 1

HCID 10902530HCID 10902530, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a suitable autoclave, equipped with mechanical stirring and external heating are added 200 parts of mono-isobutylphosphine (85%) and 300 parts of tetrahydrofuran, as solvent. With no external heating applied to the reactor, 275 parts of a 40% aqueous glyoxal solution are added with stirring at 20-25° C. The resultant solid product is filtered, and dried to give 276 parts (97% yield) of 1,4-diisobutyl-2,3,5,6-tetrahydroxy-1,4-diphosphorinane, m.p. 173-175° C.

Workup

  1. customIn a suitable autoclave, equipped
  2. temperatureexternal heating
  3. temperatureWith no external heating
  4. additionare added
  5. stirringwith stirring at 20-25° C
  6. filtrationThe resultant solid product is filtered
  7. customdried

Sources & evidence

ORD record
ord-facb568383794ffc9336c7fb49e6ac9c
Source dataset
uspto-grants-1990_05
Patent number
US04929393

Reaction notes

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