Hydrochloric Acid → HCID 70357730, compound

Participants

Reaction Steps

16.8 g of 3-(1,3,3-trimethyl-6-aza-bicyclo[3,2,1]oct-6-yl)-propionic acid ethyl ester (0.066 mol) are heated under reflux with 300 ml of 4N hydrochloric acid for 24 hours. The mixture is then completely concentrated by evaporation under reduced pressure and the crystalline residue is triturated with acetone. After filtering the crystals with suction, washing and drying, 3-(1,3,3-trimethyl-6-aza-bicyclo[3,2,1]oct-6-yl)-propionic acid hydrochloride, m.p. 183°-185° C. (decomposition) is obtained.

Provenance & Evidence