Hydrochloric Acid → HCID 70357730, compound

HRID 1651515Notes

Reaction equation

HRID 1651515 reaction equation
C([O:3][C:4](=[O:18])[CH2:5][CH2:6][N:7]1[CH2:13][C:12]2([CH3:15])[CH2:14][CH:8]1[CH2:9][C:10]([CH3:17])([CH3:16])[CH2:11]2)C.[ClH:19]>>[ClH:19].[CH3:15][C:12]12[CH2:14][CH:8]([N:7]([CH2:6][CH2:5][C:4]([OH:18])=[O:3])[CH2:13]1)[CH2:9][C:10]([CH3:17])([CH3:16])[CH2:11]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 53862841HCID 53862841, compound

Product 1

HCID 70357730HCID 70357730, compound

Procedure

16.8 g of 3-(1,3,3-trimethyl-6-aza-bicyclo[3,2,1]oct-6-yl)-propionic acid ethyl ester (0.066 mol) are heated under reflux with 300 ml of 4N hydrochloric acid for 24 hours. The mixture is then completely concentrated by evaporation under reduced pressure and the crystalline residue is triturated with acetone. After filtering the crystals with suction, washing and drying, 3-(1,3,3-trimethyl-6-aza-bicyclo[3,2,1]oct-6-yl)-propionic acid hydrochloride, m.p. 183°-185° C. (decomposition) is obtained.

Workup

  1. concentrationThe mixture is then completely concentrated by evaporation under reduced pressure
  2. customthe crystalline residue is triturated with acetone
  3. filtrationAfter filtering the crystals with suction
  4. washwashing
  5. customdrying

Sources & evidence

ORD record
ord-087b1dce5f68447185d9ae8d7c6d8c65
Source dataset
uspto-grants-1990_05
Patent number
US04929606

Reaction notes

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