反应详情

A solution of 16.4 g (60.2 mmol) of 3-(4-bromo-2,5-difluorophenyl)-2-cyclopentenone in 400 ml of THF was hydrogenated over 2.0 g of Wilkinson's catalyst at 25° C. for 18 hours. The solution was concentrated to a brown oil which was chromatographed on silica gel (E. Merck-230-400 Mesh) to remove the catalyst. The residue obtained was triturated with hexane, and the solids were filtered, washed with hexane, and dried to give 15.2 g (93%) of the title compound; mp 63°-65° C.

1. concentrationThe solution was concentrated to a brown oil which
2. customwas chromatographed on silica gel (E. Merck-230-400 Mesh)
3. customto remove the catalyst
4. customThe residue obtained
5. customwas triturated with hexane
6. filtrationthe solids were filtered
7. washwashed with hexane
8. customdried