反应详情

A solution of 17.7 g (50 mmol) of 4-[3-(acetylamino)cyclopentyl]-2,5-difluoro-β-oxobenzenepropanoic acid, ethyl ester, 11.1 g (75 mmol) triethyl orthoformate and 75 ml of acetic anhydride was refluxed for 3 hours. The solvent was removed in vacuo and the residue triturated with toluene which was also removed in vacuo, then in high vacuo at 50°. The residue, 20.1 g, was used without further purification.

1. customThe solvent was removed in vacuo
2. customthe residue triturated with toluene which
3. customwas also removed in vacuo
4. customat 50°
5. customThe residue, 20.1 g, was used without further purification