Acetic Anhydride → HCID 86743970, compound

Participants

Reaction Steps

A solution of 17.7 g (50 mmol) of 4-[3-(acetylamino)cyclopentyl]-2,5-difluoro-β-oxobenzenepropanoic acid, ethyl ester, 11.1 g (75 mmol) triethyl orthoformate and 75 ml of acetic anhydride was refluxed for 3 hours. The solvent was removed in vacuo and the residue triturated with toluene which was also removed in vacuo, then in high vacuo at 50°. The residue, 20.1 g, was used without further purification.

Provenance & Evidence