HCID 14770862, compound → HCID 14770863, compound

HRID 1651593Notes

Reaction equation

HRID 1651593 reaction equation
O1[C:5]2([CH2:9][CH2:8][CH:7]([C:10]3[CH:19]=[C:18]4[C:13]([C:14](=[O:28])[C:15]([C:23]([O:25]CC)=[O:24])=[CH:16][N:17]4[CH:20]4[CH2:22][CH2:21]4)=[CH:12][C:11]=3[F:29])[CH2:6]2)[O:4]CC1>C(O)C.Cl>[O:4]=[C:5]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:28])[C:15]([C:23]([OH:25])=[O:24])=[CH:16][N:17]3[CH:20]3[CH2:22][CH2:21]3)=[CH:12][C:11]=2[F:29])[CH2:6]1

Participants

4

Reactant 1

HCID 14770862HCID 14770862, compound

Product 1

HCID 14770863HCID 14770863, compoundYield 191.9%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

A solution of 20 g (50 mmol) of 7-(1,4-dioxaspiro[4.4]non-7-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro4-oxoquinoline-3-carboxylic acid, ethyl ester in 150 ml of ethanol and 100 ml of 6.0 M hydrochloric acid was heated at reflux for 6 hours. The solvent was removed in vacuo to give 31.6 g of the title compound.

Workup

  1. temperatureat reflux for 6 hours
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-239f4e77e5f945adbd2af023a3164fe0
Source dataset
uspto-grants-1990_05
Patent number
US04929613

Reaction notes

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