HCID 14770823, compound → HCID 14770824, compound

HRID 1651597Notes

Reaction equation

HRID 1651597 reaction equation
[C:1]([N:4]1[CH2:9][CH:8]=[C:7]([C:10]2[CH:15]=[C:14]([F:16])[C:13]([C:17]([OH:19])=[O:18])=[CH:12][C:11]=2[F:20])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>C(O)(=O)C.[Pd]>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]2[CH:15]=[C:14]([F:16])[C:13]([C:17]([OH:19])=[O:18])=[CH:12][C:11]=2[F:20])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 14770823HCID 14770823, compound

Product 1

HCID 14770824HCID 14770824, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A solution of 0.84 g (3 mmol) of 1-acetyl-4-(4-carboxy-2,5-difluorophenyl)-1,2,3,6-tetrahydropyridine in 250 ml of acetic acid with 0.5 g of 10% Pd/c catalyst was hydrogenated at 50 psi. The title compound was isolated after filtration of the catalyst, evaporation and crystallization from acetic acid-water, mp 206°-207° C.

Sources & evidence

ORD record
ord-15cd5ea78f534a17b5e35da1fb56bc24
Source dataset
uspto-grants-1990_05
Patent number
US04929613

Reaction notes

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