HCID 14770829, compound → HCID 14770865, compound

HRID 1651601Notes

Reaction equation

HRID 1651601 reaction equation
C([N:4]1[CH2:9][CH:8]=[C:7]([C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:28])[C:15]([C:23]([O:25]CC)=[O:24])=[CH:16][N:17]3[CH:20]3[CH2:22][CH2:21]3)=[CH:12][C:11]=2[F:29])[CH2:6][CH2:5]1)(=O)C>Cl>[CH:20]1([N:17]2[C:18]3[C:13](=[CH:12][C:11]([F:29])=[C:10]([C:7]4[CH2:8][CH2:9][NH:4][CH2:5][CH:6]=4)[CH:19]=3)[C:14](=[O:28])[C:15]([C:23]([OH:25])=[O:24])=[CH:16]2)[CH2:21][CH2:22]1

Participants

3

Reactant 1

HCID 14770829HCID 14770829, compound

Product 1

HCID 14770865HCID 14770865, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 0.80 g (2.01 mmol) of ethyl 7-(1-acetyl-1,2,3,6-tetrahydro-4-pyridyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate in 50 ml of 6 N hydrochloric acid was heated on a steam bath for 2.75 hours. The mixture was evaporated to dryness, redissolved in water, filtered and titrated to pH 7 with dilute sodium hydroxide. The precipitated title compound was filtered and dried.

Workup

  1. customThe mixture was evaporated to dryness
  2. dissolutionredissolved in water
  3. filtrationfiltered
  4. customThe precipitated title compound
  5. filtrationwas filtered
  6. customdried

Sources & evidence

ORD record
ord-09cafd4d842d49f58d789c1d5b179935
Source dataset
uspto-grants-1990_05
Patent number
US04929613

Reaction notes

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