HCID 18638260, compound → HCID 14770703, compound

HRID 1651734Notes

Reaction equation

HRID 1651734 reaction equation
C(OC([N:8]([CH2:20][CH:21]1[O:25][N:24]=[C:23]([Br:26])[CH2:22]1)[C:9](=[O:19])[C@H:10]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[NH2:11])=O)(C)(C)C.[C:27]([C:31]([OH:33])=[O:32])([F:30])([F:29])[F:28].C(Cl)Cl>>[F:28][C:27]([F:30])([F:29])[C:31]([OH:33])=[O:32].[NH2:11][C@H:10]([C:9]([NH:8][CH2:20][CH:21]1[O:25][N:24]=[C:23]([Br:26])[CH2:22]1)=[O:19])[CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 18638260HCID 18638260, compoundHCID 21863450Trifluoroacetic acid methylene chloride

Product 1

HCID 14770703HCID 14770703, compound

Procedure

5-(N-tert-butoxycarbonyl-L-phenylalaninamidomethyl)-3-bromo-4,5-dihydroisoxazole, 7 gm, was taken in 100 ml of 20% CF3CO2H/CH2Cl2 at 0° C. for 24 hrs. Concentration gave an oily foamy substance. 1H NMR [80 MHz, CDCl3 (H2O)]; delta 2.8-3.5 (m, 4H, CH2), 4.2-4.9 (m, 2H, CH), 4.7 (s, HOD), 7.3 ppm (s, 5H, pH).

Workup

  1. concentrationConcentration
  2. customgave an oily foamy substance

Sources & evidence

ORD record
ord-3f07533d790642ed9a09271e62f84e40
Source dataset
uspto-grants-1990_05
Patent number
US04929630

Reaction notes

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