Hydrazine hydrate (1:1) → 6-(2-amino-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

Participants

Reaction Steps

8.5 g (0.17 mol) of 99% hydrazine hydrate are added to 10.0 g (0.035 mol) of methyl 4-(2-amino-indan-5-yl)-4-oxobutyrate hydrochloride in glacial acetic acid and the mixture is boiled for 30 minutes. The mixture is evaporated in vacuo, the residue is dissolved in water and the reaction product is precipitated by neutralisation with sodium hydroxide.

Provenance & Evidence