Hydrazine hydrate (1:1) → 6-(2-amino-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

HRID 1651853Notes

Reaction equation

HRID 1651853 reaction equation
O.[NH2:2][NH2:3].Cl.[NH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:15](=O)[CH2:16][CH2:17][C:18]([O:20]C)=O)[CH:12]=2)[CH2:7]1>C(O)(=O)C>[NH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:15]3[CH2:16][CH2:17][C:18](=[O:20])[NH:2][N:3]=3)[CH:12]=2)[CH2:7]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 23050575Methyl 4-(2-amino-indan-5-yl)-4-oxobutyrate hydrochloride

Product 1

HCID 140714996-(2-amino-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

8.5 g (0.17 mol) of 99% hydrazine hydrate are added to 10.0 g (0.035 mol) of methyl 4-(2-amino-indan-5-yl)-4-oxobutyrate hydrochloride in glacial acetic acid and the mixture is boiled for 30 minutes. The mixture is evaporated in vacuo, the residue is dissolved in water and the reaction product is precipitated by neutralisation with sodium hydroxide.

Workup

  1. customThe mixture is evaporated in vacuo
  2. dissolutionthe residue is dissolved in water
  3. customthe reaction product is precipitated by neutralisation with sodium hydroxide

Sources & evidence

ORD record
ord-ee1ae706f6be499fbb63e5d2423cc233
Source dataset
uspto-grants-1990_05
Patent number
US04929754

Reaction notes

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