Triethylamine → Methyl 4-(2-o-methoxybenzenesulphonamido-indan-5-yl)-4-oxobuty rate

HRID 1651864Notes

Reaction equation

HRID 1651864 reaction equation
Cl.[NH2:2][CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:12](=[O:19])[CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16])[CH:9]=2)[CH2:4]1.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[S:28](Br)(=[O:30])=[O:29].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[S:28]([NH:2][CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:12](=[O:19])[CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16])[CH:9]=2)[CH2:4]1)(=[O:30])=[O:29]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 23050575Methyl 4-(2-amino-indan-5-yl)-4-oxobutyrate hydrochlorideHCID 23050591o-Methoxybenzenesulphonyl bromide

Product 1

HCID 14071513Methyl 4-(2-o-methoxybenzenesulphonamido-indan-5-yl)-4-oxobuty rate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared analogously to Example 5 from methyl 4-(2-amino-indan-5-yl)-4-oxobutyrate hydrochloride and o-methoxybenzenesulphonyl bromide in chloroform in the presence of triethylamine.

Sources & evidence

ORD record
ord-3356daa75cdd49b787f9fc113e8945b7
Source dataset
uspto-grants-1990_05
Patent number
US04929754

Reaction notes

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