HCID 70359768, compound → HCID 70359813, compound

HRID 1651873Notes

Reaction equation

HRID 1651873 reaction equation
[C:1]1([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16](/[C:20](/[CH3:27])=[CH:21]\[C:22]([O:24]CC)=[O:23])[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C>[C:1]1([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16](/[C:20](/[CH3:27])=[CH:21]\[C:22]([OH:24])=[O:23])[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 70359768HCID 70359768, compound

Product 1

HCID 70359813HCID 70359813, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.4 ml of 15N sodium hydroxide solution are added to 9.1 g (23.6 mmol) of ethyl 3-(2-benzenesulphonamidoindan-5-yl)-crotonate in 100 ml of ethanol and the mixture is boiled for 1 hour. The sodium salt is precipitated on cooling. It is filtered off with suction and dissolved in water. The free acid is precipitated by adding hydrochloric acid and is recrystallised from isopropanol.

Workup

  1. customThe sodium salt is precipitated
  2. temperatureon cooling
  3. filtrationIt is filtered off with suction
  4. dissolutiondissolved in water
  5. customThe free acid is precipitated
  6. additionby adding hydrochloric acid
  7. customis recrystallised from isopropanol

Sources & evidence

ORD record
ord-17d195eed8594025b4a051149a4a9a26
Source dataset
uspto-grants-1990_05
Patent number
US04929754

Reaction notes

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