Piperidine → HCID 178517240, Verbindung

HRID 1651880Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1651880
C1CCNCC1.O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1>C1CN2CCN1CC2.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.COCCOC.CS(C)=O.F[P-](F)(F)(F)(F)F.Fc1cc(F)c(-c2ccc(C(F)(F)F)cn2)[c]([Ir+][c]2cc(F)cc(F)c2-c2ccc(C(F)(F)F)cn2)c1.[Cl][Ni][Cl]>O=C1Nc2ccc(N3CCCCC3)cc2C(C#CC2CC2)(C(F)(F)F)O1

Komponenten

7

Edukt 2

HCID 8082PiperidineHCID 64139Efavirenz

Produkt 1

HCID 178517240HCID 178517240, VerbindungAusbeute 1,998 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 9237DabcoKatalysatorHCID 15773433Dichloronickel;1,2-dimethoxyethaneKatalysatorHCID 178441141HCID 178441141, VerbindungKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel3×

Reaktionsbedingungen

Temperatur
55 °C

Aufarbeitung

  1. additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
  2. aliquot25 microliter of quenched reaction mixture was taken
  3. additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

Quellen und Nachweise

ORD-Eintrag
ord-d6f017f43e534519ad3ecd0649d273f0
Quelldatensatz
Nano CN PhotoChemistry Informers Library
Originallink
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