Piperidine → HCID 178500184, 화합물

HRID 1651952노트

반응식

HRID 1651952 반응식
C1CCNCC1.COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1>C1CN2CCN1CC2.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.COCCOC.CS(C)=O.F[P-](F)(F)(F)(F)F.Fc1cc(F)c(-c2ccc(C(F)(F)F)cn2)[c]([Ir+][c]2cc(F)cc(F)c2-c2ccc(C(F)(F)F)cn2)c1.[Cl][Ni][Cl]>COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(N2CCCCC2)cc1

참가 물질

7

반응물 2

HCID 8082PiperidineHCID 15225389Methyl 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoate

생성물 1

HCID 178500184HCID 178500184, 화합물수율 0%

시약·촉매·용매 4

HCID 9237Dabco촉매HCID 15773433Dichloronickel;1,2-dimethoxyethane촉매HCID 178441141HCID 178441141, 화합물촉매HCID 679Dimethyl Sulfoxide용매3회

반응 조건

온도
55 °C

후처리

  1. additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
  2. aliquot25 microliter of quenched reaction mixture was taken
  3. additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

출처 및 근거

ORD 기록
ord-df14e5cff4ee4339b74dced854b92a85
출처 데이터셋
Nano CN PhotoChemistry Informers Library
원본 링크
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