Piperidine → HCID 178470271, 화합물

HRID 1651953노트

반응식

HRID 1651953 반응식
C1CCNCC1.CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(Br)ccc1-2>C1CN2CCN1CC2.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.COCCOC.CS(C)=O.F[P-](F)(F)(F)(F)F.[Cl][Ni][Cl].c1ccc(-c2cccc[c]2[Ir+][c]2ccccc2-c2ccccn2)nc1>CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(N3CCCCC3)ccc1-2

참가 물질

7

반응물 2

HCID 8082PiperidineHCID 10737466Ethyl 8-bromo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate

생성물 1

HCID 178470271HCID 178470271, 화합물수율 45.861%

시약·촉매·용매 4

HCID 9237Dabco촉매HCID 15773433Dichloronickel;1,2-dimethoxyethane촉매HCID 178441140HCID 178441140, 화합물촉매HCID 679Dimethyl Sulfoxide용매3회

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온도
55 °C

후처리

  1. additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
  2. aliquot25 microliter of quenched reaction mixture was taken
  3. additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

출처 및 근거

ORD 기록
ord-7665b9e0e13d41c0b9910030af451dff
출처 데이터셋
Nano CN PhotoChemistry Informers Library
원본 링크
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