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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 16528Generated: October 29, 2026

Hydrochloric Acid → HCID 68488974, compound

https://huagongshe.com/reaction/16528

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 86613443HCID 86613443—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 68488974HCID 68488974128.8%

Reaction Steps

A solution of 1,1-dimethylethyl (R)-2-[[methyl[[4-(4-bromophenoxy)phenyl]methyl]amino]methyl]-1-pyrrolidinecarboxylate (670 mg, 1.8 mmol) in a solution of 4 N hydrochloric acid in dioxane (6 mL) was stirred overnight. Solvent was removed under reduced pressure and 870 mg of (R)—N-[[4-(4-bromophenoxy)phenyl]methyl]-N-methyl-2-pyrrolidinemethanamine was isolated as the hydrochloride salt.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07737145B2
Source datasetuspto-grants-2010_06
ORD IDord-c2694de5014f4240806f87009c98ee20
Source noteuspto-grants-2010_06