Tetrahydrofuran → 1-(5-(1,3-Difluoro-2-methylpropan-2-yl)isoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)-2-fluorophenyl)urea
Reaction equation
[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[CH3:22][O:23][c:24]1[cH:25][c:26]2[c:27]([O:36][c:37]3[c:38]([F:44])[c:39]([NH2:40])[cH:41][cH:42][cH:43]3)[n:28][cH:29][n:30][c:31]2[cH:32][c:33]1[O:34][CH3:35].[F:1][CH2:2][C:3]([CH2:4][F:5])([CH3:6])[c:7]1[cH:8][c:9]([NH:12][C:13]([O:14][c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)=[O:21])[n:10][o:11]1>>[F:1][CH2:2][C:3]([CH2:4][F:5])([CH3:6])[c:7]1[cH:8][c:9]([NH:12][C:13](=[O:21])[NH:40][c:39]2[c:38]([F:44])[c:37]([O:36][c:27]3[c:26]4[cH:25][c:24]([O:23][CH3:22])[c:33]([O:34][CH3:35])[cH:32][c:31]4[n:30][cH:29][n:28]3)[cH:43][cH:42][cH:41]2)[n:10][o:11]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-dd177fbb597140dd90eaf2ba83e8a745
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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