3-Benzyloxy-pyrid-2-ylsulfonamide → 3-Hydroxypyridine-2-sulfonamide

HRID 1653624Notes

Reaction equation

HRID 1653624 reaction equation
C([O:8][C:9]1[C:10]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[C:10]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 199579343-Benzyloxy-pyrid-2-ylsulfonamide

Product 1

HCID 199579383-Hydroxypyridine-2-sulfonamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 263.7 g of 3-benzyloxy-pyrid-2-ylsulfonamide in 2.5 l of methanol is hydrogenated with the addition of 26 g of 5% Pd/C catalyst. After 23.8 l of hydrogen have been absorbed, the catalyst is filtered off. After evaporation of the methanol, 3-hydroxypyrid-2-ylsulfonamide remains in the form of a crystalline mass. Melting point 162°-164° C.

Workup

  1. customAfter 23.8 l of hydrogen have been absorbed
  2. filtrationthe catalyst is filtered off
  3. customAfter evaporation of the methanol, 3-hydroxypyrid-2-ylsulfonamide

Sources & evidence

ORD record
ord-eb95c2fac7874c788366ee6643fedcc4
Source dataset
uspto-grants-1995_04
Patent number
US05403814

Reaction notes

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