HCID 20080365, compound → HCID 131718771, compound

HRID 1653629Notes

Reaction equation

HRID 1653629 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([NH:12][C:13]([N:15]2[CH2:20][CH:19]=[CH:18][CH2:17][CH:16]2[C:21](O)=[O:22])=[O:14])=[C:4]([F:24])[CH:3]=1>C(O)C.Cl>[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:21](=[O:22])[CH:16]3[CH2:17][CH:18]=[CH:19][CH2:20][N:15]3[C:13]2=[O:14])=[C:4]([F:24])[CH:3]=1

Participants

4

Reactant 1

HCID 20080365HCID 20080365, compound

Product 1

HCID 131718771HCID 131718771, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

The solution of 1,43 g (0,004 moles) of 1[[(4-chloro-2-fluoro-5-isopropoxyphenyl)amino]carbonyl]-1,2,3,6-tetrahydro-2-pyridinecarboxylic acid in 20 ml of ethanol and 20 ml of 2N HCl is boiled under reflux for 4 hours. Rotevaporation of the reaction solution furnishes the title compound as a faintly yellow syrup, which is homogeneous by TLC (Rf=0,35 on silica gel with ethyl acetate-hexane 1:1) when visualized with a 1% KMnO4 solution.

Workup

  1. temperatureunder reflux for 4 hours

Sources & evidence

ORD record
ord-15851148864a473fbf7bcfa9c3bf1dd9
Source dataset
uspto-grants-1995_04
Patent number
US05403817

Reaction notes

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