Benzene → HCID 13574374, compound

HRID 1653630Notes

Reaction equation

HRID 1653630 reaction equation
C1C=CC=CC=1.[CH3:7][O:8][C:9]1[CH:21]=[CH:20][C:12]([O:13][CH2:14][CH2:15][CH2:16][C:17](O)=[O:18])=[CH:11][CH:10]=1.S(Cl)([Cl:24])=O>O>[CH3:7][O:8][C:9]1[CH:21]=[CH:20][C:12]([O:13][CH2:14][CH2:15][CH2:16][C:17]([Cl:24])=[O:18])=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 241BenzeneHCID 24386Thionyl ChlorideHCID 2496494-(4-methoxyphenoxy)butanoic acid

Product 1

HCID 13574374HCID 13574374, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

Benzene (70.0 cc) and 14.0 grams of γ-(p-methoxyphenoxy)butyric acid were agitated with water cooling and 5.74 cc of thionyl chloride was added dropwise. Subsequently, the mixture was agitated for 10 minutes at an internal temperature of 60° C. After the reaction had been completed, the reaction mixture was cooled and transferred to a separate flask and the solvent and excess thionyl chloride were removed in a rotary evaporator. γ-(p-Methoxyphenoxy)butyric acid chloride was obtained as white crystals.

Workup

  1. additionwas added dropwise
  2. temperaturethe reaction mixture was cooled
  3. customtransferred to a separate flask
  4. customthe solvent and excess thionyl chloride were removed in a rotary evaporator

Sources & evidence

ORD record
ord-5da6f7e9126745c5bd3491b522276710
Source dataset
uspto-grants-1995_04
Patent number
US05403811

Reaction notes

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