HCID 15239970, compound → HCID 15239971, compound

HRID 1653635Notes

Reaction equation

HRID 1653635 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][C:12]2[C:13]([C:38]([O:40][CH3:41])=[O:39])=[N:14][C:15]([N:18]([CH2:29][CH2:30][O:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)C(OCC3C=CC=CC=3)=O)=[CH:16][CH:17]=2)[N:4]=1>CO.[C].[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][C:12]2[C:13]([C:38]([O:40][CH3:41])=[O:39])=[N:14][C:15]([NH:18][CH2:29][CH2:30][O:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:16][CH:17]=2)[N:4]=1

Participants

4

Reactant 1

HCID 15239970HCID 15239970, compound

Product 1

HCID 15239971HCID 15239971, compoundYield 70.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1.12 g (2 mmol) of methyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-[N-(2-phenoxy)ethyl-N-benzyloxycarbonylamino]picolinate was catalytically reduced in 30 ml of methanol in the presence of 1 g of palladium carbon (10%). The catalyst was filtered off, and the filtrate was distilled under reduced pressure at a low temperature of not higher than 40° C., and the residual oily product was purified by column chromatography to obtain the desired product as colorless transparent oily product.

Workup

  1. filtrationThe catalyst was filtered off
  2. distillationthe filtrate was distilled under reduced pressure at a low temperature of not higher than 40° C.
  3. customthe residual oily product was purified by column chromatography

Sources & evidence

ORD record
ord-7cca9d423b8f4f9797ac02fae56c8840
Source dataset
uspto-grants-1995_04
Patent number
US05403816

Reaction notes

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