反应详情

3.1 g (10 mmol) of methyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-aminopicolinate, 2.4 g (21 mmol) of methanesulfonyl chloride and 1.5 g (11 mmol) of potassium carbonate were added to 10 ml of MEK, and the mixture was stirred and refluxed for 12 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. The residual oily product was purified by column chromatography and then crystallized from diisopropyl ether to obtain the desired product as a slightly yellow powder.

1. temperaturerefluxed for 12 hours
2. customAfter completion of the reaction
3. distillationthe solvent was distilled off under reduced pressure
4. customThe residual oily product was purified by column chromatography
5. customcrystallized from diisopropyl ether