Methanol → (2'-Fluoro-4-(hydroxymethyl)-5'-(methyloxy)-1,1'-biphenyl-2-yl)(1-methylcyclopropyl)methanol

HRID 165364Notes

Reaction equation

HRID 165364 reaction equation
[CH3:1][C:2]([Si:3]([CH3:4])([CH3:5])[O:6][CH2:7][c:8]1[cH:9][c:10]([CH:23]([OH:24])[C:25]2([CH3:28])[CH2:26][CH2:27]2)[c:11](-[c:14]2[c:15]([F:22])[cH:16][cH:17][c:18]([O:20][CH3:21])[cH:19]2)[cH:12][cH:13]1)([CH3:29])[CH3:30].[CH3:31][OH:32].[CH3:50][CH2:51][O:52][C:53]([CH3:54])=[O:55].[c:33]1([CH3:34])[cH:35][cH:36][c:37]([S:38]([O-:39])(=[O:40])=[O:41])[cH:42][cH:43]1.[nH+:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1>>[OH:6][CH2:7][c:8]1[cH:9][c:10]([CH:23]([OH:24])[C:25]2([CH3:28])[CH2:26][CH2:27]2)[c:11](-[c:14]2[c:15]([F:22])[cH:16][cH:17][c:18]([O:20][CH3:21])[cH:19]2)[cH:12][cH:13]1

Participants

6

Reactant 5

HCID 887MethanolHCID 8857Ethyl AcetateHCID 85570p-ToluenesulfonateHCID 4989215PyridiniumHCID 57706611(4-((((1,1-Dimethylethyl)(dimethyl)silyl)oxy)methyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-2-yl)(1-methylcyclopropyl)methanol

Product 1

HCID 57706703(2'-Fluoro-4-(hydroxymethyl)-5'-(methyloxy)-1,1'-biphenyl-2-yl)(1-methylcyclopropyl)methanol

Sources & evidence

ORD record
ord-3c2ed5b9837848faabc367d843579ed0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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