反应详情

2.0 g (6.5 mmol) of methyl 6-amino-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]picolinate, 1.2 g (6.5 mmol) of picolinoyl chloride hydrochloride and 2.0 g (14.8 mmol) of potassium carbonate were added to 30 ml of MEK, and the mixture was refluxed for 6 hours under stirring. After completion of the reaction, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with water and dried. The solvent was distilled off to obtain crude crystals. The crude crystals were washed with diisopropyl ether-ethyl acetate to obtain the desired product as colorless needle-like crystals.

1. temperaturethe mixture was refluxed for 6 hours
2. customAfter completion of the reaction
3. extractionextracted with ethyl acetate
4. washThe extract was washed with water
5. customdried
6. distillationThe solvent was distilled off
7. customto obtain crude crystals
8. washThe crude crystals were washed with diisopropyl ether-ethyl acetate