反应详情

Potassium cyanide (651 mg, 10 mmol) and ammonium chloride (588 mg, 11 mmol) are dissolved in water (2.6 mL) with stirring. Pyrimidine-5-carboxaldehyde (1.08 g, 10 mmol) in methanol (2.6 mL) is added to the clear solution rapidly, giving first a yellow, then a dark red solution, and mildly exothermic reaction. The water is evaporated after three hours stirring, and the reddish residue is chromatographed (silica, chloroform/methanol) to give a yellow solid 1.1 g (82%) identified as product ms m/z=134.

1. customgiving first a yellow, then
2. customa dark red solution, and mildly exothermic reaction
3. customThe water is evaporated after three hours
4. stirringstirring
5. customthe reddish residue is chromatographed (silica, chloroform/methanol)