反应详情

Amino(pyrimidin-5-yl)acetamide (950 mg, 6.7 mmol) is suspended in a mixture of 50 ml water and concentrated hydrochloric acid (13.3 mmol). The mixture is hydrogenated at 26 psig over 300 mg Pd-on-carbon 10% in a Parr hydrogenator for 3h. Then the suspension is filtered and the filter rinsed twice with hot water (20 ml). The filtrate can be evaporated in vacuo to give 1.41 g yellow oil (92%). The oil is crystallized from anhydrous methanol/THF to give 1.33 g (87%) white crystals, identified by 300 MHz nmr.

1. filtrationThen the suspension is filtered
2. washthe filter rinsed twice with hot water (20 ml)
3. customThe filtrate can be evaporated in vacuo