2-Naphthalenemethanol → 5-Fluoro-3-(naphth-2-ylmethoxy)bromobenzene

HRID 1653757Notes

Reaction equation

HRID 1653757 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][OH:12].[Br:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[C:16](F)[CH:15]=1>>[F:20][C:18]1[CH:17]=[C:16]([O:12][CH2:11][C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)[CH:15]=[C:14]([Br:13])[CH:19]=1

Participants

3

Reactant 2

HCID 741282-NaphthalenemethanolHCID 1363131-Bromo-3,5-difluorobenzene

Product 1

HCID 224086065-Fluoro-3-(naphth-2-ylmethoxy)bromobenzeneYield 92%

Procedure

Using the procedure described in the first paragraph of the portion of Example 3 which is concerned with the preparation of starting materials, 2-naphthalenemethanol was reacted with 1-bromo-3,5-difluorobenzene to give 5-fluoro-3-(naphth-2-ylmethoxy)bromobenzene (92%), m.p. 65°-67° C.

Sources & evidence

ORD record
ord-f19f9733aba84d49a5819fbe6a086129
Source dataset
uspto-grants-1995_04
Patent number
US05403859

Reaction notes

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