2-Methylpyridine → 1-(Pyridin-2-yl)propan-2-one

HRID 1653841Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C([Li])CCC.CN(C)[C:15](=[O:17])[CH3:16]>>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[CH2:1][C:15](=[O:17])[CH3:16]

Participants

Reactant 3

HCID 79752-Methylpyridine

HCID 31374Dimethylacetamide

HCID 178418339Butyllithium

Product 1

HCID 959101-(Pyridin-2-yl)propan-2-one

Procedure

This was prepared from 2-methylpyridine, butyllithium and N,N-dimethylacetamide according to the procedure of R. Cassity, L. T. Taylor and J. F. Wolfe, J. Org. Chem., 43(11), 2286, (1986).

Sources & evidence

ORD record: ord-1bcc1e898ae24a5d81f18123edb07bb2
Source dataset: uspto-grants-1995_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05403934

Reaction notes

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