反应详情

The ester from Example 1d (23.7 g, 58 mmol) was dissolved in 1M NaOH (190 ml) and refluxed for 6 h. The cooled solution was acidified with an excess of 6M HCl. The precipitated formed was allowed to stand for 2 h, filtered off and washed with water (3×200 ml). The white product was dried at 60° C. in vacuo. Yield 21.7 g (95%).

1. temperaturerefluxed for 6 h
2. customThe precipitated formed
3. filtrationfiltered off
4. washwashed with water (3×200 ml)
5. customThe white product was dried at 60° C. in vacuo