HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 8-(3-Trifluoromethylphenyl)pyrido[2,3-d]pyridazin-5-(6H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-(3-Trifluoromethylbenzoyl)nicotinic acid | HCID 20078895 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-(3-Trifluoromethylphenyl)pyrido[2,3-d]pyridazin-5-(6H)-one | HCID 20078863 | — |
Reaction Steps
A mixture of 2-(3-trifluoromethylbenzoyl)nicotinic acid (1.5 g) and hydrazine hydrate (0.4 g) in ethanol was heated at the reflux temperature for 5 hours. On cooling and reduction of the volume of solvent by evaporation, a precipitate formed which was collected by filtration, to give the title compound as a white solid, 1.08 g, m.p. 210°-215° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05405826 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-9fe5b2bec79f4dce9192e2e36735ee5b |
| Source note | uspto-grants-1995_04 |