Water → HCID 178427906, compound

HRID 1654070Notes

Reaction equation

HRID 1654070 reaction equation
Cl.[Cl:2][C:3]1[C:4]([CH3:15])=[C:5]([N:9]2[NH:13][C:12](=[NH:14])[O:11][NH:10]2)[CH:6]=[CH:7][CH:8]=1.O.C(=O)([O-])O.[Na+]>ClCCl>[Cl:2][C:3]1[C:4]([CH3:15])=[C:5]([N:9]2[NH:13][C:12](=[NH:14])[O:11][NH:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 962WaterHCID 516892Sodium BicarbonateHCID 178427907HCID 178427907, compound

Product 1

HCID 178427906HCID 178427906, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
5 °C

Procedure

1.23 g (5 mmole) of the 3-(3-chloro-2-methylphenyl)-1,2 3,4-oxatrizole-5-imine hydrochloride prepared in Example 1 were dissolved in a two-phase system consisting of 30 ml of water and 10 ml of dichloromethane. The mixture was cooled in an ice bath to 5° C., and subsequently 0.84 g (10 mmole) of sodium hydrogen carbonate was carefully added in small quantities. After terminated development of carbon dioxide the mixture was stirred vigorously for about 10 minutes, whereafter the the organic phase was separated and evaporated.

Workup

  1. customAfter terminated development of carbon dioxide the mixture
  2. customwhereafter the the organic phase was separated
  3. customevaporated

Sources & evidence

ORD record
ord-957e6ded4ae64d37a662f4847e5c5159
Source dataset
uspto-grants-1995_04
Patent number
US05405857

Reaction notes

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