4-(3-Chloro-2-hydroxypropyl)-1-diphenylmethylpiperazine → HCID 15228131, compound

HRID 1654082Notes

Reaction equation

HRID 1654082 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.Cl[CH2:14][CH:15]([OH:36])[CH2:16][N:17]1[CH2:22][CH2:21][N:20]([CH:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:19][CH2:18]1.CC([O-])(C)C.[K+]>>[C:30]1([CH:23]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:20]2[CH2:19][CH2:18][N:17]([CH2:16][CH:15]([OH:36])[CH2:14][O:1][C:2]3[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]4[C:3]=3[CH:4]=[CH:5][CH:6]=[N:7]4)[CH2:22][CH2:21]2)[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

4

Reactant 3

HCID 103601754-(3-Chloro-2-hydroxypropyl)-1-diphenylmethylpiperazineHCID 23665647Potassium tert-butoxideHCID 135508003HCID 135508003, compound

Product 1

HCID 15228131HCID 15228131, compound

Procedure

Following the same procedure as in Example 23-(c), reaction and treatment were carried out using 360 mg of the above synthesized 5-hydroxy-8-methylquinoline, 1.39 g of 4-(3-chloro-2-hydroxypropyl)-1-diphenylmethylpiperazine and 300 mg of t-BuOK in order to obtain 120 mg of 5-[3-(4-diphenylmethylpiperazine-1-yl)-2-hydroxypropoxy]-8-methylquinoline.

Workup

  1. customas in Example 23-(c), reaction and treatment

Sources & evidence

ORD record
ord-08c85ec87ef44e669703d6d0ab99c0a6
Source dataset
uspto-grants-1995_04
Patent number
US05405843

Reaction notes

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